Genotype-dependent effects of GABAergic agents on sedative properties of ethanol

Two lines of mice, selectively bred for differential sensitivity to the soporific effects of ethanol (ETOH), were administered GABAergic drugs in an effort to evaluate a role for GABA in ETOH sensitivity. ETOH sensitive Long-Sleep mice (LS) showed potentiated ETOH sedation when administered bicucull...

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Bibliographic Details
Published in:Psychopharmacologia 1989-01, Vol.98 (4), p.518-523
Main Authors: DUDEK, B. C, PHILLIPS, T. J
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Animals
Bicuculline - pharmacology
Biological and medical sciences
Ethanol - pharmacology
gamma-Aminobutyric Acid - physiology
Genetics, Behavioral
Genotype
Hypnotics and Sedatives
Male
Medical sciences
Mice
Mice, Inbred A
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred Strains
Muscimol - pharmacology
Pentobarbital - pharmacology
Picrotoxin - pharmacology
Species Specificity
Toxicology
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Summary:Two lines of mice, selectively bred for differential sensitivity to the soporific effects of ethanol (ETOH), were administered GABAergic drugs in an effort to evaluate a role for GABA in ETOH sensitivity. ETOH sensitive Long-Sleep mice (LS) showed potentiated ETOH sedation when administered bicuculline, muscimol and aminooxyacetic acid (AOAA). ETOH-insensitive SS mice exhibited reduced ETOH sedation in the presence of the antagonists, bicuculline and picrotoxin, and potentiated sedation in the presence of muscimol and AOAA. These changes in narcosis duration were interpreted as central effects, since blood ethanol levels at waking from ETOH sedation varied with GABAergic drug treatment. Picrotoxin antagonized pentobarbital-induced narcosis in both lines, but to a greater extent in SS mice. These and other experiments with a genetically heterogeneous stock suggest GABA involvement in genotype-dependent ETOH sensitivity, but do not support a simple role of GABA receptor involvement.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00441952