Is there evidence of a role of the phosphoinositol-cycle in the myocardium?

The recent findings on a more general involvement of phospholipids in signal transduction and on the different roles of inositolphospholipids in particular, thoroughly complicate research in this field. It becomes increasingly evident that measuring [3H]inositolphosphate formation alone will never p...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1989-06, Vol.88 (1-2), p.65-72
Main Author: de Chaffoy de Courcelles, D
Format: Article
Language:English
Subjects:
Animals
Chemical Phenomena
Chemistry
Myocardium - metabolism
Phosphatidylinositols - metabolism
Phosphatidylinositols - physiology
phosphoinositides
Receptors, Adrenergic, alpha - metabolism
Receptors, Muscarinic - metabolism
Signal Transduction
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Summary:The recent findings on a more general involvement of phospholipids in signal transduction and on the different roles of inositolphospholipids in particular, thoroughly complicate research in this field. It becomes increasingly evident that measuring [3H]inositolphosphate formation alone will never provide insight into the complex machinery of cellular signalling. Certainly for the heart in which the role(s) of the inositolphospholipids is far from clarified, the novel trends provide new directions for research.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00223425