MRI in Cockayne syndrome type I

MRI findings are reported from two patients with Cockayne syndrome (CS) type I, aged 11 and 37 years. Changes were compatible with diffuse white matter hypomyelination. Basal ganglia calcification was present in both, marked cerebellar atrophy in the older patient. MRI may support the diagnosis of C...

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Bibliographic Details
Published in:Neuroradiology 1989-01, Vol.31 (3), p.276-277
Main Authors: BOLTSHAUSER, E, YALCINKAYA, C, WICHMANN, W, REUTTER, F, PRADER, A, VALAVANIS, A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - pathology
Cerebellum - pathology
Child
Cockayne Syndrome - classification
Cockayne Syndrome - diagnosis
Complex syndromes
Dwarfism - diagnosis
Female
Humans
Magnetic Resonance Imaging
Medical genetics
Medical sciences
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Summary:MRI findings are reported from two patients with Cockayne syndrome (CS) type I, aged 11 and 37 years. Changes were compatible with diffuse white matter hypomyelination. Basal ganglia calcification was present in both, marked cerebellar atrophy in the older patient. MRI may support the diagnosis of CS in the appropriate clinical context. The view that CS is a dysmyelinating disorder is further substantiated.
ISSN:0028-3940
1432-1920
DOI:10.1007/BF00344359