Composite carcinoid‐adenocarcinoma of the stomach associated with multiple gastric carcinoids and nonantral gastric atrophy

A case of multiple gastric carcinoids and nonantral atrophic gastritis in which the larger tumor was a composite carcinoid‐adenocarcinoma is presented. The two components of the composite tumor immunohistochemically showed clear‐cut diverging functional differentiations although the available eviden...

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Bibliographic Details
Published in:Cancer 1989-10, Vol.64 (7), p.1534-1539
Main Authors: Caruso, M. L., Pilato, F. P., D'Adda, T., Baggi, M. T., Fucci, L., Valentini, A. M., Lacatena, M., Bordi, Cesare
Format: Article
Language:English
Subjects:
Adenocarcinoma - analysis
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Atrophy
Biomarkers, Tumor - analysis
Carcinoid Tumor - analysis
Carcinoid Tumor - pathology
Carcinoid Tumor - surgery
Female
Gastrectomy
Gastric Mucosa - pathology
Humans
Metaplasia
Middle Aged
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Polyps - pathology
Stomach - pathology
Stomach Neoplasms - analysis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
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Summary:A case of multiple gastric carcinoids and nonantral atrophic gastritis in which the larger tumor was a composite carcinoid‐adenocarcinoma is presented. The two components of the composite tumor immunohistochemically showed clear‐cut diverging functional differentiations although the available evidence supported a common histogenesis from the metaplastic intestinal epithelium of the gastric mucosa. The carcinoid tissue of the composite tumor, which showed “atypical” features, also differed from the other, pure carcinoids, in which the histologic appearance was “typical.” Total gastrectomy performed 1 month after the original gastric resection with antrectomy disclosed regressive changes in the endocrine cell proliferations of the gastric stump consistent with the withdrawal of a stimulating effect of the antral gastrin.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19891001)64:7<1534::AID-CNCR2820640730>3.0.CO;2-H