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True Histiocytic Lymphoma as a Second Neoplasm in a Follicular Centroblastic-Centrocytic Lymphoma

We report on a patient who developed a true histiocytic lymphoma, 16 years after initial diagnosis of a follicular low grade centroblastic-centrocytic lymphoma with several recurrences. We consider, out of gene rearrangement and immunohistochemical studies, that in this case, true histiocytic lympho...

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Published in:Pathology, research and practice research and practice, 1997, Vol.193 (4), p.319-322
Main Authors: Rodilla, C. Martin, Aceñero, J. Fernández, Mayor, L. Peña, Carmona, A. Alvarez
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description We report on a patient who developed a true histiocytic lymphoma, 16 years after initial diagnosis of a follicular low grade centroblastic-centrocytic lymphoma with several recurrences. We consider, out of gene rearrangement and immunohistochemical studies, that in this case, true histiocytic lymphoma is a second neoplasm in the evolutive course of the low grade lymphoma. The natural history of a low grade malignant lymphoma is to develop into a high grade large cell lymphoma and, if a second neoplasm appears, it is usually an epithelial tumor. This fact makes our report unique, as it would be, to our knowledge, the first case of true histiocytic lymphoma as the second neoplasm of another lymphoma.
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ispartof Pathology, research and practice, 1997, Vol.193 (4), p.319-322
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source ScienceDirect Journals
subjects Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Fatal Outcome
Humans
Immunohistochemistry
Low grade follicular lymphoma
Lymph Nodes - pathology
Lymphoma, Follicular - immunology
Lymphoma, Follicular - pathology
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Middle Aged
Mononuclear phagocytic cell
Neoplasms, Second Primary - immunology
Neoplasms, Second Primary - pathology
Reticulum cell sarcoma
Submandibular Gland
True histiocytic lymphoma
title True Histiocytic Lymphoma as a Second Neoplasm in a Follicular Centroblastic-Centrocytic Lymphoma
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