HLA Antigens in Depressed, Demented, and Nondemented Elderly

To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. The frequency for antigen Aw32 was significantly higher in the group of patie...

Full description

Saved in:
Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 1989-04, Vol.2 (2), p.70-75
Main Authors: Small, Gary W., Matsuyama, Steven S., Komanduri, Ramanujam, Spar, James E., Fairbanks, Lynn
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Alzheimer Disease - immunology
Dementia - immunology
Depressive Disorder - immunology
Female
HLA Antigens - analysis
Humans
Male
Middle Aged
Reference Values
Sex Factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To identify HLA antigen associations with geriatric depression, the authors typed 36 elderly patients with major depression and, for comparison, 36 patients with Alzheimer-type dementia and 29 nondemented elderly controls. The frequency for antigen Aw32 was significantly higher in the group of patients with major depression (14%) than in the demented (0%) and control (3%) groups. The frequencies for antigens Aw32 (22%) and Bw51 (22%) were significantly higher in the subgroup of 23 patients with endogenous depression than in the demented (Aw32 = 0%; Bw51 = 11%) and the control (Aw32 = 3%; Bw51 = 0%) groups. Although these results were derived from a relatively small sample (n = 101) and become nonsignificant when corrected for multiple comparisons, they suggest that HLA antigen associations may be present for only certain depressive subtypes in geriatric depression. (J Geriatr Psychiatry Neurol 1989;2:70-75).
ISSN:0891-9887
1552-5708
DOI:10.1177/089198878900200203