No prediction of recurrence of meningiomas by PCNA and Ki-67 immunohistochemistry

Immunohistochemistry for the expression of the proliferation markers proliferating cell nuclear antigen (PCNA) and Ki-67 was studied in 16 non recurring meningiomas, 11 meningiomas recurring as benign tumors, 6 recurring as atypical meningiomas and in 9 recurring as malignant meningiomas. Non recurr...

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Bibliographic Details
Published in:Journal of neuro-oncology 1997-09, Vol.34 (3), p.241-246
Main Authors: MØLLER, M.-L, BRAENDSTRUP, O
Format: Article
Language:English
Subjects:
Adult
Aged
Benign
Biological and medical sciences
Brain cancer
Female
Humans
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Malignancy
Medical sciences
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - immunology
Meningioma - diagnosis
Meningioma - immunology
Neoplasm Recurrence, Local - immunology
Neurology
Predictive Value of Tests
Proliferating cell nuclear antigen
Proliferating Cell Nuclear Antigen - analysis
Statistical analysis
Surgery
Tumor cells
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Immunohistochemistry for the expression of the proliferation markers proliferating cell nuclear antigen (PCNA) and Ki-67 was studied in 16 non recurring meningiomas, 11 meningiomas recurring as benign tumors, 6 recurring as atypical meningiomas and in 9 recurring as malignant meningiomas. Non recurring meningiomas were defined in this study as tumors without recurrence at least 8 years after surgery. In addition 16 benign recurrences, 14 atypical- and 12 malignant meningiomas were studied. In each group great variation of labeling indices (LI) = per cent of tumor cells labeled was observed, especially of PCNA LIs. The non recurring meningiomas displayed lower mean LI for PCNA and Ki-67 than did the recurring meningiomas of all groups but the differences were not statistically significant. The same pattern was seen when totally resected tumors were studied alone. Benign-, atypical-, and malignant meningiomas had labeling indices that were related to the grade of malignancy. Only PCNA LIs of atypical- and malignant meningiomas were statistically significantly higher than PCNA LIs of non recurring meningiomas. The study indicates that PCNA and Ki-67 are of minor value as predictors of recurrence of benign meningiomas.
ISSN:0167-594X
1573-7373
DOI:10.1023/A:1005794700267