Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl

The skin reactivity to histamine was measured in 10 healthy and 10 atopic subjects after the ingestion of single doses of loratadine 10 mg, cetirizine diHCl 10 mg and placebo, in a double-blind cross-over randomized study. The anti-H1 effect of cetirizine diHCl proved to be significantly more rapid,...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1989-01, Vol.36 (6), p.617-619
Main Authors: KONTOU-FILI, K, PALEOLOGOS, G, HERAKLEOUS, M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cetirizine
Cyproheptadine - analogs & derivatives
Cyproheptadine - pharmacology
Double-Blind Method
Histamine - pharmacology
Histamine and antagonists. Allergy
Histamine H1 Antagonists
Humans
Hydroxyzine - analogs & derivatives
Hydroxyzine - pharmacology
Loratadine
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Random Allocation
Skin - drug effects
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Summary:The skin reactivity to histamine was measured in 10 healthy and 10 atopic subjects after the ingestion of single doses of loratadine 10 mg, cetirizine diHCl 10 mg and placebo, in a double-blind cross-over randomized study. The anti-H1 effect of cetirizine diHCl proved to be significantly more rapid, more pronounced and longer lasting than that of loratadine.
ISSN:0031-6970
1432-1041
DOI:10.1007/bf00637746