Failure of absorption of baclofen after rectal administration

We wished to determine the degree to which baclofen was absorbed from an aqueous vehicle after rectal administration. A comparison was made to absorption after oral administration. After oral administration, the baclofen half-lie was 2.3 to 3.4 hours and peak serum concentrations were achieved from...

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Bibliographic Details
Published in:Pediatric neurology 1997-05, Vol.16 (4), p.351-352
Main Authors: Kriel, Robert L., Krach, Linda E., Hoff, Davi S., Gormley, Mark, Jones-Saete, Carolyn
Format: Article
Language:English
Subjects:
Absorption - physiology
Administration, Oral
Administration, Rectal
Adult
Baclofen - pharmacokinetics
Biological and medical sciences
Female
Humans
Medical sciences
Muscle
Pharmacology. Drug treatments
Treatment Failure
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Summary:We wished to determine the degree to which baclofen was absorbed from an aqueous vehicle after rectal administration. A comparison was made to absorption after oral administration. After oral administration, the baclofen half-lie was 2.3 to 3.4 hours and peak serum concentrations were achieved from 1 to 2.1 hours after administration. No measurable absorption was observed after rectal administration of the drug in any subject. Rectal administration of baclofen is not a clinically sound treatment option when oral administration of the drug is not possible. For patients receiving chronic baclofen therapy, other medications such as a benzodiazepine should be considered at times when oral administration of medication is not possible.
ISSN:0887-8994
1873-5150
DOI:10.1016/S0887-8994(97)00033-7