Sustained-release and instant-release verapamil in treatment of angina pectoris

The efficacy of a sustained-release preparation of verapamil (verapamil-SR) has been compared with that of a conventional instant-release formulation (verapamil-IR) in 10 patients with stable angina pectoris treated for 3 weeks with both preparations. The diurnal serum concentrations of verapamil an...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1989-01, Vol.36 (6), p.625-627
Main Authors: JESPERSEN, C. M, KLITGAARD, N. A, NIELSEN, H, FISCHER HANSEN, J
Format: Article
Language:English
Subjects:
Angina Pectoris - drug therapy
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Cardiovascular system
Delayed-Action Preparations
Double-Blind Method
Electrocardiography
Exercise Test
Female
Hemodynamics
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Verapamil - administration & dosage
Verapamil - analogs & derivatives
Verapamil - blood
Verapamil - therapeutic use
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Summary:The efficacy of a sustained-release preparation of verapamil (verapamil-SR) has been compared with that of a conventional instant-release formulation (verapamil-IR) in 10 patients with stable angina pectoris treated for 3 weeks with both preparations. The diurnal serum concentrations of verapamil and norverapamil did not differ significantly during treatment with verapamil-IR 120 mg t.i.d. and verapamil-SR 360 mg once daily, but verapamil-SR 240 mg produced significantly lower serum concentrations. The differences did not affect the exercise capacity or the occurrence of ST-segment depression during maximal exercise. Verapamil-SR was well tolerated. A multiple instant-release dosage regime can now be replaced by once daily administration of the sustained-release preparation.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00637748