Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins

Synapsins are neuronal phosphoproteins that coat synaptic vesicles, bind to the cytoskeleton, and are believed to function in the regulation of neurotransmitter release. Molecular cloning reveals that the synapsins comprise a family of four homologous proteins whose messenger RNA's are generate...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-09, Vol.245 (4925), p.1474-1480
Main Authors: Südhof, Thomas C., Czernik, Andrew J., Kao, Hung-Teh, Takei, Kohji, Johnston, Patricia A., Horiuchi, Atsuko, Kanazir, Selma D., Wagner, Michael A., Perin, Mark S., De Camilli, Pietro, Greengard, Paul
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Antibodies
Base Sequence
DNA
Genetics
membrane proteins
Messenger RNA
Molecular Sequence Data
Nerve proteins
Nerve tissue proteins
Nerve Tissue Proteins - genetics
Nerves
Nervous system
Neural transmission
Neuropeptides - genetics
Phosphoproteins - genetics
Phosphorylation
Proteins
reviews
Sequence Homology, Nucleic Acid
Structure-Activity Relationship
Synapses
Synapsins
Synaptic transmission
synaptic vesicles
Synaptic Vesicles - physiology
Ungulates
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Summary:Synapsins are neuronal phosphoproteins that coat synaptic vesicles, bind to the cytoskeleton, and are believed to function in the regulation of neurotransmitter release. Molecular cloning reveals that the synapsins comprise a family of four homologous proteins whose messenger RNA's are generated by differential splicing of transcripts from two genes. Each synapsin is a mosaic composed of homologous amino-terminal domains common to all synapsins and different combinations of distinct carboxylterminal domains. Immunocytochemical studies demonstrate that all four synapsins are widely distributed in nerve terminals, but that their relative amounts vary among different kinds of synapses. The structural diversity and differential distribution of the four synapsins suggest common and different roles of each in the integration of distinct signal transduction pathways that modulate neurotransmitter release in various types of neurons.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2506642