Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing

Six experimental groups of young (7-month-old) and aged (24–32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamine E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were...

Full description

Saved in:
Bibliographic Details
Published in:Molecular aspects of medicine 1997, Vol.18, p.247-250
Main Authors: Armeni, T., Tomasetti, M., Svegliati Baroni, S., Saccucci, F., Marra, M., Pieri, C., Littarru, G.P., Principato, G., Battino, M.
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Antioxidants - analysis
coenzyme Q
Coenzymes
dietary restriction
Food Deprivation
glutathione
Glutathione - analysis
Hydrogen Peroxide - analysis
Lipid Peroxidation
Longevity
Mitochondria, Liver - metabolism
Oxidative Stress
rat liver mitochondria
Rats
Ubiquinone - analogs & derivatives
Ubiquinone - analysis
Vitamin E Deficiency - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six experimental groups of young (7-month-old) and aged (24–32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamine E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by age and dietary treatment. Coenzyme Q 9 and CoQ 10 showed the highest levels in the oldest rats where ageing, as well as other oxidative stresses, could induce ubiquinone biosynthesis.
ISSN:0098-2997
1872-9452
DOI:10.1016/S0098-2997(97)00021-6