An uncertain silence

Transcriptional silencing is the most well-studied epigenetic phenomenon in yeast. In Saccharomyces cerevisiae, silencing has recently been found at previously unidentified loci. In addition to the silent mating-type loci and telomeres, genes within the ribosomal DNA and, perhaps, at undefined aging...

Full description

Saved in:
Bibliographic Details
Published in:Trends in Genetics 1997-08, Vol.13 (8), p.308-313
Main Authors: Sherman, Joyce M., Pillus, Lorraine
Format: Article
Language:English
Subjects:
Acetylation
epigenetics
Fungal Proteins - genetics
Fungal Proteins - metabolism
gene expression
Gene Expression Regulation, Fungal
gene silencing
genetic regulation
histones
literature reviews
Models, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Telomere
transcription (genetics)
transcription factors
Transcription, Genetic
transcriptional silencing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transcriptional silencing is the most well-studied epigenetic phenomenon in yeast. In Saccharomyces cerevisiae, silencing has recently been found at previously unidentified loci. In addition to the silent mating-type loci and telomeres, genes within the ribosomal DNA and, perhaps, at undefined aging loci are silenced. Efficiency of silencing at different loci varies and is affected by competition between the loci and by the involvement of different factors in distinct protein complexes. The recent discovery of conserved gene families encoding proteins related to modulators of acetylation and deacetylation suggests mechanisms for differential regulation of silencing at known loci and the existence of additional, as yet undiscovered, silenced loci.
ISSN:0168-9525
DOI:10.1016/S0168-9525(97)01198-0