Modeling transmembrane helical oligomers

Recently, methods for the analysis and design of water-soluble, oligomeric bundles of α helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phosphola...

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Bibliographic Details
Published in:Current opinion in structural biology 1997-08, Vol.7 (4), p.486-494
Main Authors: Dieckmann, Gregg R, DeGrado, William F
Format: Article
Language:English
Subjects:
Calcium-Binding Proteins - chemistry
Computer Simulation
Glycophorin - chemistry
Influenza A virus - chemistry
Membrane Proteins - chemistry
Models, Molecular
Protein Conformation
Viral Matrix Proteins - chemistry
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Summary:Recently, methods for the analysis and design of water-soluble, oligomeric bundles of α helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phospholamban, and the M 2 protein from influenza A virus exemplify this general approach.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(97)80111-X