Persistence of Human Leukocyte Antigen (HLA) Antibodies After One Year in Children Receiving Cryopreserved Valved Allografts

This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes o...

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Bibliographic Details
Published in:The American journal of cardiology 1997-08, Vol.80 (3), p.358-359
Main Authors: Shaddy, Robert E, Thompson, Dixie D, Osborne, Karen A, Hawkins, John A, Fuller, Thomas C
Format: Article
Language:English
Subjects:
Adolescent
Aortic Valve - transplantation
Biological and medical sciences
Child
Child, Preschool
Cryopreservation
Epitopes
Heart Defects, Congenital - surgery
Histocompatibility Antigens Class I - immunology
Humans
Infant
Infant, Newborn
Isoantibodies - blood
Medical sciences
Prospective Studies
Pulmonary Valve - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Time Factors
Transplantation, Homologous
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Description
Summary:This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes of the patients, i.e., the panel-reactive antibody was directed against major alloantigen groups that were not expressed by the antibody responders.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00366-4