Point Status of lipid and lipoprotein standardization

Cholesterol and triglyceride standardization procedures have been used extensively and continuously since the 1950s. Definitive and Reference Methods, as well as primary and secondary standards, have been developed and maintained as the basis for evaluating the accuracy of results by various methods...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1997-08, Vol.43 (8), p.1306-1310
Main Authors: McNamara, Judith R, Leary, Elizabeth Teng, Ceriotti, Ferruccio, Boersma-Cobbaert, Christa M, Cole, Thomas G, Hassemer, David J, Nakamura, Masakazu, Packard, Christopher J, Seccombe, David W, Kimberly, Mary M, Myers, Gary L, Cooper, Gerald R
Format: Article
Language:English
Subjects:
Apolipoproteins - blood
Biological and medical sciences
Blood Chemical Analysis - standards
Cardiovascular system
Centers for Disease Control and Prevention (U.S.)
Cholesterol - blood
Coronary Disease - blood
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lipids - blood
Lipoproteins - blood
Medical sciences
National Institutes of Health (U.S.)
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Reference Standards
Reference Values
Risk Factors
Societies, Scientific
Triglycerides - blood
United States
World Health Organization
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Summary:Cholesterol and triglyceride standardization procedures have been used extensively and continuously since the 1950s. Definitive and Reference Methods, as well as primary and secondary standards, have been developed and maintained as the basis for evaluating the accuracy of results by various methods in many laboratories. But, although standardization efforts for apolipoprotein A-I and B measurements have been reported in detail in the scientific literature, much less has been reported in the area of total and lipoprotein cholesterol and triglyceride standardization efforts. Standardized cholesterol and triglyceride concentrations, determined in multiple large epidemiological and clinical studies, have been instrumental to the National Cholesterol Education Program panels that have assessed the lipoprotein values associated with risk of coronary disease, and have determined the cutpoints that are now used extensively by physicians to guide diagnosis and treatment of individual patients.
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/43.8.1306