EFFECTS OF 5-HT3 RECEPTOR AGONISTS ON VOLUNTARY ETHANOL INTAKE IN RATS MAINTAINED ON A LIMITED ACCESS PROCEDURE

Recent evidence from a variety of laboratory studies suggests that the central effects of ethanol (EtOH) are mediated by serotonin 5-HT3 receptors. Notably, EtOH is able to potentiate 5-HT action on 5-HT3 ionophore, and 5-HT3 antagonists are known to reduce certain effects of EtOH. In the present st...

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Published in:Alcohol and alcoholism (Oxford) 1997-07, Vol.32 (4), p.455-462
Main Authors: DYR, WANDA, KOSTOWSKI, WOJCIECH
Format: Article
Language:English
Subjects:
Alcohol Drinking
Alcoholism and acute alcohol poisoning
Animals
Biguanides - administration & dosage
Biguanides - pharmacology
Biological and medical sciences
Central Nervous System - drug effects
Central Nervous System - physiology
Central Nervous System Depressants - administration & dosage
Central Nervous System Depressants - pharmacology
Ethanol - administration & dosage
Ethanol - pharmacology
Male
Medical sciences
Rats
Rats, Wistar
Receptors, Serotonin - physiology
Serotonin - administration & dosage
Serotonin - analogs & derivatives
Serotonin - pharmacology
Serotonin Receptor Agonists - pharmacology
Toxicology
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container_title Alcohol and alcoholism (Oxford)
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KOSTOWSKI, WOJCIECH
description Recent evidence from a variety of laboratory studies suggests that the central effects of ethanol (EtOH) are mediated by serotonin 5-HT3 receptors. Notably, EtOH is able to potentiate 5-HT action on 5-HT3 ionophore, and 5-HT3 antagonists are known to reduce certain effects of EtOH. In the present study, we evaluated the effects of two agonists of 5-HT3 receptors, 2-methyl-5-HT (2-Me-5-HT) and m-chlorophenylbiguanide (m-CPBG) that were microinjected i.c.v. and into the nucleus accumbens (NAC) on EtOH intake in Wistar rats with high EtOH preference. 2-Me-5-HT given i.c.v. (1 and 10 μg per rat) and into the NAC (bilaterally 1 and 10 μg per site) significantly reduced EtOH intake in the limited access paradigm (2 h session). On the other hand m-CPBG was inactive after intra-NAC administration. It is concluded that central 5-HT3 receptors are involved in the regulation of EtOH consumption.
doi_str_mv 10.1093/oxfordjournals.alcalc.a008280
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source Oxford Journals Online
subjects Alcohol Drinking
Alcoholism and acute alcohol poisoning
Animals
Biguanides - administration & dosage
Biguanides - pharmacology
Biological and medical sciences
Central Nervous System - drug effects
Central Nervous System - physiology
Central Nervous System Depressants - administration & dosage
Central Nervous System Depressants - pharmacology
Ethanol - administration & dosage
Ethanol - pharmacology
Male
Medical sciences
Rats
Rats, Wistar
Receptors, Serotonin - physiology
Serotonin - administration & dosage
Serotonin - analogs & derivatives
Serotonin - pharmacology
Serotonin Receptor Agonists - pharmacology
Toxicology
title EFFECTS OF 5-HT3 RECEPTOR AGONISTS ON VOLUNTARY ETHANOL INTAKE IN RATS MAINTAINED ON A LIMITED ACCESS PROCEDURE
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