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Heterologous biopharmaceutical protein expression in Streptomyces
The commercial production of human proteins in recombinant microorganisms for therapeutic use is well established. Systems have been developed to exploit the natural ability of certain bacteria to secrete properly folded, bioactive proteins into the extracellular medium. The streptomycetes are a rel...
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| Published in: | Trends in biotechnology (Regular ed.) 1997-08, Vol.15 (8), p.315-320 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c523t-beb8bed977e7f4ea2d56f47614053c08d1b3094ba77cb4d4a91448702c69a71c3 |
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| cites | cdi_FETCH-LOGICAL-c523t-beb8bed977e7f4ea2d56f47614053c08d1b3094ba77cb4d4a91448702c69a71c3 |
| container_end_page | 320 |
| container_issue | 8 |
| container_start_page | 315 |
| container_title | Trends in biotechnology (Regular ed.) |
| container_volume | 15 |
| creator | Binnie, Craig Douglas Cossar, J. Stewart, Donald I.H. |
| description | The commercial production of human proteins in recombinant microorganisms for therapeutic use is well established. Systems have been developed to exploit the natural ability of certain bacteria to secrete properly folded, bioactive proteins into the extracellular medium. The streptomycetes are a relatively well-characterized group of nonpathogenic filamentous bacteria that have the capacity to secrete large amounts of protein. In particular,
Streptomyces lividans has the ability to secrete human proteins at a commercially viable level, thanks to relatively wellestablished plasmid-based expression systems, a high-biomass fermentation process and a low level of endogenous protease activity. |
| doi_str_mv | 10.1016/S0167-7799(97)01062-7 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0167-7799 |
| ispartof | Trends in biotechnology (Regular ed.), 1997-08, Vol.15 (8), p.315-320 |
| issn | 0167-7799 1879-3096 |
| language | eng |
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| source | Elsevier |
| subjects | Bacterial Proteins - biosynthesis Bacteriology Biological and medical sciences Biopharmaceutics - trends Biotechnology Fundamental and applied biological sciences. Psychology Humans Metabolism. Enzymes Microbiology Recombinant Proteins - biosynthesis Streptomyces - metabolism Streptomyces lividans |
| title | Heterologous biopharmaceutical protein expression in Streptomyces |
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