Physico-chemical study of the radiopharmaceuticals 99mTc-DMSA, 99mTc-EDTA and 99mTc-DTPA interaction with plasmatic proteins

This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA < 99mTc-DMSA(C 1) < 99mTc-EDTA < 99mTc-DMSA(C 2) where C 1 and C 2 represe...

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Bibliographic Details
Published in:International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1989, Vol.40 (6), p.536-538
Main Authors: Domenech, R.Garcia, Mendez, O.Abril, Alvarez, J.Galvez, Marti, A.Farga
Format: Article
Language:English
Subjects:
Blood Proteins
Edetic Acid
Organotechnetium Compounds
Pentetic Acid
Protein Binding
Succimer
Sulfhydryl Compounds
Technetium
Technetium Tc 99m Dimercaptosuccinic Acid
Technetium Tc 99m Pentetate
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Summary:This report studies the binding rate of the radiopharmaceuticals 99mTc-DTPA, 99mTc-EDTA and 99mTc-DMSA to plasmatic proteins. The proteins bind to the tested radiopharmaceuticals in the following sequence: 99mTc-DTPA < 99mTc-DMSA(C 1) < 99mTc-EDTA < 99mTc-DMSA(C 2) where C 1 and C 2 represent two different Tc-DMSA complexes. The thermodynamic study suggests a quantitative relationship of radiopharmaceutical:protein = 1:1 and an almost nonexistent influence of the temperature, which means that the interacting forces in this process are relatively weak.
ISSN:0883-2889
DOI:10.1016/0883-2889(89)90141-X