Elevation of factor VII activity and mass in young adults at risk of ischemic heart disease

The Northwick Park Heart Study found that elevation of factor VII in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. The present study was designed to determine whether factor VII elevation is present at a younger age and whether zymogen or activated factor...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 1989-10, Vol.14 (4), p.941-946
Main Authors: Hoffman, Carol J., Miller, Robin H., Lawson, William E., Hultin, Mae B.
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens
Biological and medical sciences
Cardiology. Vascular system
Cholesterol - blood
Coronary Disease - blood
Coronary Disease - genetics
Coronary heart disease
Factor VII - analysis
Factor VII - immunology
Factor VIIa - analysis
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Prospective Studies
Risk Factors
Triglycerides - blood
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Summary:The Northwick Park Heart Study found that elevation of factor VII in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. The present study was designed to determine whether factor VII elevation is present at a younger age and whether zymogen or activated factor VII is responsible for this elevation. A group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched normal subjects at low risk of ischemic heart disease and 15 older subjects with established ischemic heart disease (mean age 49.7 years). Factor VII procoagulant, coupled amidolytic and antigenic assays, as well as fasting serum triglyceride and cholesterol assays, were performed on all three groups. Factor VII antigen and coagulant activity was significantly elevated in first degree relatives, as was factor VII antigen in the patients with ischemic heart disease. The increased factor VII level in these subjects was caused by elevated factor VII zymogen, not activated factor VII. The results of this study, combined with those of previous studies, suggest that factor VII may be a useful additional marker of the risk for ischemic heart disease and merits further investigation.
ISSN:0735-1097
1558-3597
DOI:10.1016/0735-1097(89)90470-1