MRI of a family with focal abnormalities of gyration

Focal abnormalities of gyration (FAG) are developmental disorders that may occur in isolated patients or, as in the case being reported, as part of a familial disorder. Analysis of individuals in a family spanning three generations was carried out using MRI. Abnormalities, present in all members of...

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Bibliographic Details
Published in:Neuroradiology 1997-08, Vol.39 (8), p.605-608
Main Authors: MUNTANER, L, PEREZ-FERRON, J. J, HERRERA, M, ROSELL, J, TABOADA, D, CLIMENT, S
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain Diseases - diagnosis
Brain Diseases - genetics
Cerebral Cortex - abnormalities
Cerebral Cortex - pathology
Choristoma - diagnosis
Choristoma - genetics
Electroencephalography
Epilepsies, Partial - diagnosis
Epilepsies, Partial - genetics
Female
Humans
Karyotyping
Magnetic Resonance Imaging
Male
Malformations of the nervous system
Medical sciences
Middle Aged
Neurology
Neurons
Pedigree
Tomography, X-Ray Computed
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Summary:Focal abnormalities of gyration (FAG) are developmental disorders that may occur in isolated patients or, as in the case being reported, as part of a familial disorder. Analysis of individuals in a family spanning three generations was carried out using MRI. Abnormalities, present in all members of generations II and III, included focal cortical dysplasia (three patients), focal cortical infolding (two patients) and schizencephaly (one patient); associated minor anomalies, such as white matter abnormalities, were seen in the remaining three members of generations II and III. MRI recognition of FAG in the family being reported proved useful in defining their phenotypical expression and providing proper counselling for individual family members.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340050477