Hodgkin’s cells express CD83, a dendritic cell lineage associated antigen

• Published in: Pathology 1997, Vol.29 (3), p.294-299
• Main Authors: Sorg, Ursula R., Morse, Timothy M., Nigel Patton, W., Hock, Barry D., Angus, Helen B., Robinson, Bridget A., Colls, Barry M., Hart, Derek N.J.
• Format: Article
• Language: English
• Subjects: Antibodies, Monoclonal; Antigens, CD - analysis; Biological and medical sciences; CD83; CD83 Antigen; Cell Lineage; dendritic cells; Dendritic Cells - immunology; Hematologic and hematopoietic diseases; Hodgkin Disease - immunology; Hodgkin Disease - pathology; Hodgkins disease; Humans; Immunoenzyme Techniques; Immunoglobulins - analysis; Immunophenotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Membrane Glycoproteins - analysis; Tropical medicine
• ISSN: 0031-3025; 1465-3931
• DOI: 10.1080/00313029700169125

Hodgkin’s cells (HC) are considered to be the malignant cells of Hodgkin’s disease (HD), but despite extensive studies, no conclusive evidence has emerged regarding their non-malignant counterpart and the ontogeny of these cells remains controversial. The analysis of a possible dendritic cell (DC) origin of HC has been hampered to date by the lack of a DC lineage specific marker. The expression of the two DC-associated antigens CD83 and CMRF-44, the B lymphocyte restricted molecule CD79, and the costimulator molecule CD86, was examined in lymph nodes from 23 HD patients using immunohistological techniques. The majority of HC expressed the CD83 (22/23) and CD86 antigens (20/23), whereas expression of the CMRF-44 antigen was variable (10/23) and usually only a subpopulation of HC stained. In contrast, the CD79 antigen was absent from most HC (17/23). The presence of the CD83 antigen on HC in the absence of the CD79 antigen supports a possible DC lineage odgin for some HC. Regardless of its role in lineage assignment, CD83 may become a useful immunohistological marker for HD as the CD83 antigen was present on most HC.