Analysis of a model for the pathogenesis of AIDS

According to a previously proposed mathematical model, the pathogenesis of acquired immunodeficiency syndrome (AIDS) could be explained by two phenomena: direct human immunodeficiency virus (HIV) infection of CD4 + T-cell populations and ongoing generation and selection of HIV mutants with increasin...

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Bibliographic Details
Published in:Mathematical biosciences 1997-10, Vol.145 (1), p.27-46
Main Authors: Stilianakis, Nikolaos I., Dietz, Klaus, Schenzle, Dieter
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - physiopathology
AIDS/HIV
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
HIV - genetics
HIV - physiology
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Mathematics
Medical sciences
Models, Biological
Virus Replication
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Summary:According to a previously proposed mathematical model, the pathogenesis of acquired immunodeficiency syndrome (AIDS) could be explained by two phenomena: direct human immunodeficiency virus (HIV) infection of CD4 + T-cell populations and ongoing generation and selection of HIV mutants with increasing replicative capacity. In the present paper, the results obtained with this model are described in more detail. For different values of biologically interpretable parameters, the model predicts very different patterns of CD4 + T-cell decline after primary infection. With the assumption of a variability of 10% to 25% of three parameters between infected individuals, the model yields a realistic distribution curve of the incubation period to AIDS.
ISSN:0025-5564
1879-3134
DOI:10.1016/S0025-5564(97)00018-7