Experimental infection of nude mice as a model for Sarcocystis neurona-associated encephalitis

The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoal parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related...

Full description

Saved in:
Bibliographic Details
Published in:Parasitology research (1987) 1997, Vol.83 (7), p.706-711
Main Authors: MARSH, A. E, BARR, B. C, LAKRITZ, J, NORDHAUSEN, R, MADIGAN, J. E, CONRAD, P. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - parasitology
Disease Models, Animal
Encephalitis - parasitology
Experimental protozoal diseases and models
Infectious diseases
Liver - parasitology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Nude
Mice, SCID
Neurons - parasitology
Parasitic diseases
Protozoal diseases
Sarcocystis - pathogenicity
Sarcocystosis - parasitology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoal parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.
ISSN:0932-0113
1432-1955
DOI:10.1007/s004360050323