The outcome of an in vitro fertilization program in women with polycystic ovary syndrome

The objective of this study was to examine the efficacy of D-triptorelin in the long protocol and follicle-stimulating hormone (FSH) in an IVF-embryo transfer program in a group of patients with polycystic ovary syndrome (PCOS) who had earlier failed to respond or did not conceive after clomiphene c...

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Bibliographic Details
Published in:Gynecological endocrinology 1997, Vol.11 (4), p.259-262
Main Authors: Grochowski, D., Kulikowski, M., Wolczynski, S., Kuczynski, W., Szamatowicz, M.
Format: Article
Language:English
Subjects:
Chorionic Gonadotropin - therapeutic use
Embryo Transfer
Female
Fertilization in Vitro
Follicle Stimulating Hormone - therapeutic use
GONADOTROPIN-RELEASING HORMONE AGONISTS
Humans
IN VITRO FERTILIZATION
Ovulation Induction
POLYCYSTIC OVARY SYNDROME
Pregnancy
Treatment Outcome
Triptorelin Pamoate - therapeutic use
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Summary:The objective of this study was to examine the efficacy of D-triptorelin in the long protocol and follicle-stimulating hormone (FSH) in an IVF-embryo transfer program in a group of patients with polycystic ovary syndrome (PCOS) who had earlier failed to respond or did not conceive after clomiphene citrate (CC)/human menopausal gonadotropin (hMG) or flare up' gonadotropin-releasing hormone agonist (GnRHa)ZhMG stimulation. Eighty-nine women with PCOS (based on typical ultrasound criteria) had 1-3 treatment cycles without success. The stimulation protocol was changed to D-triptorelin given in midluteal phase and when pituitary desensitization was achieved, FSH administration was started. The clinical pregnancy rate per transfer in this 'negatively selected' group of PCOS patients was 29%. This was the same as the rate for a group of women with tubal factor, as was the spontaneous miscarriage rate. Although the use of GnRH agonists in the long protocol increases the costs of treatment, the number of cancelled cycles is reduced. The pregnancy rate increased in this group of women with PCOS.
ISSN:0951-3590
1473-0766
DOI:10.3109/09513599709152543