Simulation of lindane kinetics in rats

The kinetics of lindane were modelled in the male rat with a physiologically-based pharmacokinetic (PB-PK) model. The model was parameterized by using reference physiological parameter values and partition coefficients that were reported earlier in the literature. First order biotransformation and g...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 1997-09, Vol.122 (1), p.1-9
Main Authors: DeJongh, Joost, Blaauboer, Bas J
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Administration, Oral
Animals
Biological and medical sciences
Brain - metabolism
Calibration
Hexachlorocyclohexane - administration & dosage
Hexachlorocyclohexane - blood
Hexachlorocyclohexane - pharmacokinetics
Injections, Intraperitoneal
Kinetics
Lindane
Liver - metabolism
Male
Medical sciences
Models, Biological
Pesticides, fertilizers and other agrochemicals toxicology
Physiologically-based pharmacokinetic model
Rats
Rats, Wistar
Reproducibility of Results
Toxicology
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Summary:The kinetics of lindane were modelled in the male rat with a physiologically-based pharmacokinetic (PB-PK) model. The model was parameterized by using reference physiological parameter values and partition coefficients that were reported earlier in the literature. First order biotransformation and gastro-intestinal absorption constants for lindane were obtained by visually fitting the model to literature data on lindane disposition in vivo after a single oral dose. The model was validated by simulating the disposition of lindane in vivo after single intraperitoneal and chronic oral dosage and comparing simulated with experimental results. It was concluded that the present model can adequately simulate most of the reported data on lindane kinetics.
ISSN:0300-483X
1879-3185
DOI:10.1016/S0300-483X(97)00070-X