QUANTITATION OF THE THROMBOTIC EFFECTS IN ARTERY AND VEIN OF THE INCREASE IN COAGULATION FACTORS DURING NORMAL PREGNANCY IN THE RAT

Coagulation factors increase and fibrinolysin activity decreases in pregnant women. While the nett change in thrombotic tendency is unmeasured, venous thromboembolism increases five-fold in this group. We measured thrombus formation in vein and artery on standard platinum wires in 45 near-term pregn...

Full description

Saved in:
Bibliographic Details
Published in:Thrombosis research 1997-08, Vol.87 (4), p.359-362
Main Authors: Iomhair, Maura Mhic, Lavelle, S.M
Format: Article
Language:English
Subjects:
Animals
Arteries - pathology
aspirin/dipyridamole
Biological and medical sciences
Blood and lymphatic vessels
Blood Coagulation Factors - analysis
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
EACA
ellagic acid
Female
Fibrinolysis
heparin
hypercoagulable
Medical sciences
Pregnancy
Pregnancy Complications, Cardiovascular - blood
Pregnancy Complications, Cardiovascular - pathology
Pregnancy, Animal - blood
Rats
Rats, Sprague-Dawley
Thrombosis
Veins - pathology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coagulation factors increase and fibrinolysin activity decreases in pregnant women. While the nett change in thrombotic tendency is unmeasured, venous thromboembolism increases five-fold in this group. We measured thrombus formation in vein and artery on standard platinum wires in 45 near-term pregnant rats, 19 pregnant for the first time and 26 for the second time, and in 33 never-pregnant controls. No significant increase in arterial thrombus occurred in the pregnant rats. Venous thrombus, however, increased by 65% in rats pregnant for the first time and 176% in those pregnant for the second time, compared to never-pregnant animals. Their mean increase in coagulation factors VIII, X, V, VII and II varied from 165 to 268%. Factor VIII level (r=0.59, p
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(97)00139-4