FLUVASTATIN AND TISSUE FACTOR PATHWAY INHIBITOR IN TYPE IIA AND IIB HYPERLIPIDEMIA AND IN ACUTE MYOCARDIAL INFARCTION

Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor that regulates tissue factor-induced blood coagulation. In an open-label 8-week study, 20 hypercholesterolemic patients (10 type IIa and 10 type IIb) were enrolled and given fluvastatin 40 mg once daily at bedtime. At baseline (af...

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Bibliographic Details
Published in:Thrombosis research 1997-08, Vol.87 (4), p.397-403
Main Authors: Lorena, M., Perolini, S., Casazza, F., Milani, M., Cimminiello, C.
Format: Article
Language:English
Subjects:
Adult
Anticholesteremic Agents - administration & dosage
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Enzyme-Linked Immunosorbent Assay
Fatty Acids, Monounsaturated - administration & dosage
Female
Fluvastatin
Humans
hypercholesterolemia
Hyperlipoproteinemia Type II - blood
Hyperlipoproteinemia Type II - drug therapy
Indoles - administration & dosage
Lipids - blood
Lipoproteins - blood
Male
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - drug therapy
Pharmacology. Drug treatments
tissue factor pathway inhibitor
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Summary:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor that regulates tissue factor-induced blood coagulation. In an open-label 8-week study, 20 hypercholesterolemic patients (10 type IIa and 10 type IIb) were enrolled and given fluvastatin 40 mg once daily at bedtime. At baseline (after a 4-week controlled diet) and at week 8, total cholesterol, total triglycerides and lipoprotein subfractions were assessed. TFPI antigen levels were measured at the same time by ELISA. We also measured TFPI concentrations in 10 control subjects and in 10 patients at the time of and ten days after acute myocardial infarction. In type IIa patients fluvastatin reduced total cholesterol levels by 26% and LDL-cholesterol by 30% ( P
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(97)00143-6