A NOVEL VARIANT OF STAPHYLOKINASE GENE FROM STAPHYLOCOCCUS AUREUS ATCC 29213

The processes of hemostasis and thrombolysis are elegantly regulated in order to ensure normal functions of vascular system. A search for new plasminogen activators as thrombolytic agents has been carried out for the purpose of clinical applications to modulate thrombolytic processes. In the current...

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Bibliographic Details
Published in:Thrombosis research 1997-08, Vol.87 (4), p.387-395
Main Authors: Kim, Seung-Ho, Chun, Hong-Sung, Han, Moon Hi, Park, Na-Young, Suk, Kyoungho
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Bacteriology
Base Sequence
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cloning, Molecular
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
fibrinolysis
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Medical sciences
Metabolism. Enzymes
Metalloendopeptidases - genetics
Microbiology
Molecular Sequence Data
Pharmacology. Drug treatments
S. aureus
Sequence Alignment
Staphylococcus aureus - genetics
staphylokinase
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Summary:The processes of hemostasis and thrombolysis are elegantly regulated in order to ensure normal functions of vascular system. A search for new plasminogen activators as thrombolytic agents has been carried out for the purpose of clinical applications to modulate thrombolytic processes. In the current work, several strains and clinical isolates of Staphylococcus aureus were screened for the fibrinolytic activity. The DNA sequences of staphylokinase gene in the strains expressing 15 kDa protein with staphylokinase activity were determined and subsequently compared with three known staphylokinase gene sequences. From the sequence comparison a new variant of staphylokinase gene has been identified in ATCC 29213 strain. The gene product needs to be further characterized and tested for the therapeutic potential. © 1997 Elsevier Science Ltd
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(97)00142-4