Poststress glucose mitigates behavioral impairment in rats in the “learned helplessness” model of psychopathology

Three experiments examined the effects of poststress glucose treatment in the learned helplessness model of psychopathology in rats. In experiment 1, rats were given access to water or 40% aqueous glucose immediately following exposure to inescapable tailshocks or simple restraint in a 2 × 2 factori...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 1997-09, Vol.42 (5), p.324-334
Main Authors: Minor, Thomas R., Saade, Samar
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
behavioral depression
Biological and medical sciences
brain metabolism
Depression
Electroshock
glucose
Glucose - pharmacology
Helplessness, Learned
inescapable shock
Learned helplessness
Male
Medical sciences
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - drug effects
Psychopathology. Psychiatry
Rats
Rats, Sprague-Dawley
Restraint, Physical
Space life sciences
Stress, Psychological - drug therapy
Stress, Psychological - psychology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three experiments examined the effects of poststress glucose treatment in the learned helplessness model of psychopathology in rats. In experiment 1, rats were given access to water or 40% aqueous glucose immediately following exposure to inescapable tailshocks or simple restraint in a 2 × 2 factorial design. Inescapably shocked rats failed to drink the glucose solution during the poststress interval and failed to show any improvement 24 hours after stress induction in shuttle-escape performance. Consequently, all rats received preexposure to a sweetened glucose cocktail in an attempt to increase poststress ingestion following inescapable shock treatment in experiment 2. Under these conditions, poststress intake of the glucose cocktail eliminated behavioral impairment in inescapably shocked rats relative to water-treated shocked rats and water- and glucose-treated restrained controls. Experiment 3 demonstrated that glucose prophylaxis occurs in the absence of sucrose when rats are preexposed to a 40% glucose solution prior to stress induction.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(96)00467-2