Flow-injection biamperometric determination of epinephrine

A flow-injection manifold is proposed for the determination of epinephrine. The experimental procedure is based on the indirect biamperometric detection of the drug by using Fe(III)-Fe(II) as an indicating redox system and a flow-through detector with two polarized Pt wire electrodes. The calibratio...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1997-08, Vol.15 (12), p.1821-1828
Main Authors: Garcia Mateo, J.V., Kojlo, Anatol
Format: Article
Language:English
Subjects:
Adrenaline
Analysis
Biamperometry
Biological and medical sciences
Catecholamines
Electrochemistry
Electrodes
Epinephrine
Epinephrine - analysis
Ferric Compounds
Ferrous Compounds
Flow injection
Flow Injection Analysis
General pharmacology
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Sensitivity and Specificity
Time Factors
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Summary:A flow-injection manifold is proposed for the determination of epinephrine. The experimental procedure is based on the indirect biamperometric detection of the drug by using Fe(III)-Fe(II) as an indicating redox system and a flow-through detector with two polarized Pt wire electrodes. The calibration graph is linear over the range 0.3–20 μg ml−1 of epinephrine. The relative standard deviation for the determination of 10 μg ml−1 of epinephrine is 1.5% (n = 25) and the sample throughput is 153 h−1. The method was applied to the determination of epinephrine in two commercially available pharmaceutical preparations.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(96)02018-3