In Vivo Evidence for the Link Between l‐ and d‐Serine Metabolism in Rat Cerebral Cortex

: To obtain an insight into the metabolic pathways of endogenous d‐serine in mammalian brains, we have investigated in the infant rat the effects of systemic administration of l‐serine, d‐serine, and related amino acids, including glycine and threonine, on the amino acid contents in the cerebral cor...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurochemistry 1997-09, Vol.69 (3), p.1286-1290
Main Authors: Takahashi, Katsunobu, Hayashi, Fumihiko, Nishikawa, Toru
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Biochemistry and metabolism
Biological and medical sciences
Central nervous system
Cerebral cortex
Cerebral Cortex - metabolism
Chromatography, High Pressure Liquid
d‐Serine
Fundamental and applied biological sciences. Psychology
Glycine
Glycine - metabolism
Glycine - pharmacology
Infant rat
Kinetics
l‐Serine
Male
Mammals
Rats
Rats, Wistar
Serine - metabolism
Stereoisomerism
Threonine - metabolism
Threonine - pharmacology
Time Factors
Vertebrates: nervous system and sense organs
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: To obtain an insight into the metabolic pathways of endogenous d‐serine in mammalian brains, we have investigated in the infant rat the effects of systemic administration of l‐serine, d‐serine, and related amino acids, including glycine and threonine, on the amino acid contents in the cerebral cortex. Intraperitoneal injection of l‐serine induced a rapid and transient elevation of the levels of l‐serine itself in the neocortex, with its peak at 3 h post injection, and a delayed and prolonged increase in d‐serine contents from 1.5 h to at least 24 h thereafter. Similarly, a significant augmentation in cerebral d‐serine contents was observed 6 h after intraperitoneal administration of glycine, which also elevated the cortical l‐serine levels. In contrast, l‐threonine injection affected the concentrations of neither d‐ nor l‐serine in the cortex of the pups. d‐Serine given systemically, in turn, increased the neocortical contents of l‐serine as well as d‐serine itself, but failed to alter those of glycine and l‐threonine. These in vivo data suggest the possible link between metabolic pathways of d‐ and l‐serine in the cerebral cortex of the rat.
ISSN:0022-3042
1471-4159
DOI:10.1046/j.1471-4159.1997.69031286.x