Reversible middle cerebral artery embolization in dogs without intracranial surgery

Using dogs, we developed an intravascular model for reversible middle cerebral artery occlusion that does not involve intracranial surgery or enucleation. Using silicone plastic plugs with a suture embedded within them, we embolized the middle cerebral artery in 19 dogs via the cervical carotid arte...

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Bibliographic Details
Published in:Stroke (1970) 1989-10, Vol.20 (10), p.1368-1376
Main Authors: PURDY, P. D, DEVOUS, M. D. SR, WHITE, C. L. III, BATJER, H. H, SAMSON, D. S, BREWER, K, HODGES, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Brain Ischemia - etiology
Brain Ischemia - pathology
Cerebral Angiography
Cerebral Arterial Diseases - etiology
Cerebral Arterial Diseases - pathology
Disease Models, Animal
Dogs
Medical sciences
Nervous system involvement in other diseases. Miscellaneous
Neurology
Prostheses and Implants
Silicones
Sutures
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Summary:Using dogs, we developed an intravascular model for reversible middle cerebral artery occlusion that does not involve intracranial surgery or enucleation. Using silicone plastic plugs with a suture embedded within them, we embolized the middle cerebral artery in 19 dogs via the cervical carotid artery. The free end of the suture remained accessible in the neck, and after variable dwell times traction was placed on the suture and the plug was withdrawn. Placement of the plug in the middle cerebral artery produced ischemia in the basal ganglia. The degree and distribution of cortical ischemia were variable as evidence by the pathologically documented scattered nature of infarcts that resulted when the plug was left permanently in the middle cerebral artery and when it was removed after 1 or 2 hours. Angiography demonstrated occlusion of the middle cerebral artery with the plug in place as well as reperfusion when the plug was withdrawn. This modification of a previously described model of middle cerebral artery occlusion provides an opportunity to study structural, physiologic, and biochemical events occurring in acutely hypoperfused cerebral tissue as well as critical changes leading to irreversible injury without the disadvantages of surgical manipulation required by all previous models of reversible cerebral ischemia.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.20.10.1368