Immunity Costs and Behavioural Modulation in Male Laboratory Mice ( Mus musculus) Exposed to the Odours of Females

• Published in: Physiology & behavior 1997-10, Vol.62 (4), p.857-866
• Main Authors: Barnard, C.J, Behnke, J.M, Gage, A.R, Brown, H, Smithurst, P.R
• Format: Article
• Language: English
• Subjects: Animals; Behavior, Animal - physiology; Behavioral psychophysiology; Biological and medical sciences; Corticosterone; Corticosterone - blood; Female; Female odours; Fundamental and applied biological sciences. Psychology; Immunocompetence - physiology; Immunodepression; Immunology and behavior; Male; Mice; Mice testosterone; Odorants; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Testosterone - blood
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/S0031-9384(97)00249-7

In a previous study, male laboratory mice experimentally immunodepressed with anti-thymocyte serum (ATS) showed changes in behaviour (aggression, general locomotory activity, and sleeping) and testosterone secretion that are consistent with decision-making being modulated adaptively with respect to immunocompetence. We tested this idea further by repeating the experiment with the addition of female odours (soiled sawdust) to the home cages of males following ATS/control treatment. We predicted that, in the presence of cues suggesting reproductive opportunity, immunodepressed males would trade off potential immunity costs by failing to modulate behaviour. This expectation was borne out in that ATS-treated mice showed no change in aggression, locomotory activity, mounting, or sleeping relative to control animals, and mice overall showed significant differences in behaviour in the expected direction compared with a previous study in which female odours were not presented. However, despite the lack of difference in behaviour between ATS and control treatments, there was still evidence of a degree of behavioural modulation in relation to measures of immunocompetence.