Effects of visceral fat and weight loss on lipoprotein(a) concentration in subjects with obesity

• Published in: Obesity research 1997-07, Vol.5 (4), p.332-337
• Main Authors: Zamboni, M, Facchinetti, R, Armellini, F, Turcato, E, Andreis, I.A.B, Bosello, O
• Format: Article
• Language: English
• Subjects: ABDOMINAL FAT; Adipose Tissue; ANIMAL FATS; ANTHROPOMETRIC DIMENSIONS; AZUCAR EN SANGRE; BAISSE DE POIDS; BIOLOGICAL RHYTHMS; BLOOD LIPIDS; BLOOD SUGAR; Body Composition; Body Mass Index; BODY MEASUREMENTS; CORPS GRAS ANIMAL; CORRELATION; Diet, Reducing; DIETAS RESTRICTAS EN ENERGIA; DISTRIBUTION; Energy Intake; ENERGY RESTRICTED DIETS; Female; FEMME; GRAISSE ABDOMINALE; GRASA ABDOMINAL; GRASAS ANIMALES; HEMOLIPIDOS; HOMBRES; HOMME; Humans; INSULIN; INSULINA; INSULINE; LIPIDE SANGUIN; Lipids - blood; LIPOPROTEIN METABOLISM; Lipoprotein(a) - blood; LIPOPROTEINAS; LIPOPROTEINE; LIPOPROTEINS; Lp(a); Male; MEDICION DEL CUERPO; MEN; MENOPAUSE; MENSURATION CORPORELLE; METABOLISM; METABOLISME; METABOLISMO; MUJERES; Obesity - blood; Obesity - diet therapy; OVERWEIGHT; REDUCCION DEL PESO; REGIME ALLEGE EN ENERGIE; REGIONAL BODY FAT DISTRIBUTION; RITMOS BIOLOGICOS; RYTHME BIOLOGIQUE; SOBREPESO; SUBCUTANEOUS FAT; SUCRE DU SANG; SURPOIDS; Tomography, X-Ray Computed; Viscera; visceral fat; Weight Loss; WEIGHT REDUCTION; WOMEN
• ISSN: 1071-7323; 1550-8528
• DOI: 10.1002/j.1550-8528.1997.tb00560.x

We studied the relationships between regional body fat distribution and metabolic variables with lipoprotein(a) [Lp(a)] as well as the effects of weight loss on Lp(a) in 25 women and 9 men with obesity. Regional body fat distribution, as evaluated by the use of computed tomography; Lp(a); and fasting glucose, insulin, cholesterol, and triglycerides were analyzed before and after a very low-energy diet. No significant correlations were found between visceral, subcutaneous, and total fat and Lp(a) or between metabolic variables and Lp(a). All anthropometric variables significantly decreased after a very low-energy diet. Fasting glucose, insulin, triglycerides, and cholesterol significantly decreased after a very low-energy diet. No significant changes in Lp(a) concentration after a very low-energy diet were found. The correlation between the initial values of Lp(a) and changes of Lp(a) after a very low-energy diet was slightly significant (p = 0.33, p 0.06). In conclusion, our study shows that Lp(a) is not influenced by obesity, visceral fat, metabolic variables, or weight loss induced by a very low-energy diet