A translocation between 3q21 and 12q24 in a patient with minimally differentiated acute myeloid leukemia (AML-MO)

Only a small number of reports have described the cytogenetic analysis of minimally differentiated acute myeloid leukemia (AML, MO). We performed a cytogenetic analysis on a patient with AML (MO) with a normal platelet count. It revealed a chromosomal translocation between chromosome bands 3q21 and...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1997-09, Vol.97 (2), p.90-93
Main Authors: Yamagata, Noboru, Shimazaki, Chihiro, Kikuta, Takehisa, Hirai, Hideyo, Sumikuma, Toshiya, Sudo, Yoshikazu, Ashihara, Eishi, Goto, Hideo, Inaba, Tohru, Fujita, Naohisa, Nakagawa, Masao
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Differentiation
Chromosome Aberrations
Chromosome Banding
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 3
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Translocation, Genetic
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Summary:Only a small number of reports have described the cytogenetic analysis of minimally differentiated acute myeloid leukemia (AML, MO). We performed a cytogenetic analysis on a patient with AML (MO) with a normal platelet count. It revealed a chromosomal translocation between chromosome bands 3q21 and 12q24. 3q. Abnormalities in AML are known to be associated with normal or elevated platelet counts. 3q21 and 12q24 are common translocation sites in AML patients, but this is the first report of translocation t(3;12)(q21;q24) in an AML patient.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(96)00339-1