Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes. Our analysis of neuroblastoma cell lines with 1p and p73...

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Bibliographic Details
Published in:Cell 1997-08, Vol.90 (4), p.809-819
Main Authors: Kaghad, Mourad, Bonnet, Helene, Yang, Annie, Creancier, Laurent, Biscan, Jean-Christophe, Valent, Alexandre, Minty, Adrian, Chalon, Pascale, Lelias, Jean-Michel, Dumont, Xavier, Ferrara, Pascual, McKeon, Frank, Caput, Daniel
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Cell Division - drug effects
Chromosome Mapping
Chromosomes, Human, Pair 1
Cyclin-Dependent Kinase Inhibitor p21
Cyclins - biosynthesis
Dactinomycin - pharmacology
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
DNA-Binding Proteins - radiation effects
Gene Deletion
Gene Expression
Genes, Tumor Suppressor
Heterozygote
Humans
Molecular Sequence Data
Neuroblastoma - genetics
Nuclear Proteins - chemistry
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Nuclear Proteins - radiation effects
Protein Synthesis Inhibitors - pharmacology
Tumor Cells, Cultured
Tumor Protein p73
Tumor Suppressor Protein p53 - chemistry
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins
Ultraviolet Rays
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Description
Summary:We describe a gene encoding p73, a protein that shares considerable homology with the tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes. Our analysis of neuroblastoma cell lines with 1p and p73 loss of heterozygosity failed to detect coding sequence mutations in remaining p73 alleles. However, the demonstration that p73 is monoallelically expressed supports the notion that it is a candidate gene in neuroblastoma. p73 also has the potential to activate p53 target genes and to interact with p53. We propose that the disregulation of p73 contributes to tumorigenesis and that p53-related proteins operate in a network of developmental and cell cycle controls.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80540-1