Haemochromatosis gene mutation in hepatocellular cancer

Willis et al used a genetic test to estimate the incidence of hepatocellular cancer among 3,600 individuals predicted to be homozygous for the HLA-H nucleotide 845G to A mutation. The penetrance of the 845A homozygous genotype is low with respect to hepatocellular cancer in this population.

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Published in:The Lancet (British edition) 1997-08, Vol.350 (9077), p.565-566
Main Authors: Willis, G, Wimperis, JZ, Lonsdale, R, Jennings, BA
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cancer
Carcinoma, Hepatocellular - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Genes
Genotype
Hemochromatosis - genetics
Hemochromatosis Protein
Histocompatibility Antigens Class I - genetics
HLA Antigens - genetics
Humans
Liver
Liver Neoplasms - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Membrane Proteins
Mutation
Tumors
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cited_by cdi_FETCH-LOGICAL-c416t-8acf030562b43cab76ee26b940266c9e0da983339d29f4c19b597fca50cd11183
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container_issue 9077
container_start_page 565
container_title The Lancet (British edition)
container_volume 350
creator Willis, G
Wimperis, JZ
Lonsdale, R
Jennings, BA
description Willis et al used a genetic test to estimate the incidence of hepatocellular cancer among 3,600 individuals predicted to be homozygous for the HLA-H nucleotide 845G to A mutation. The penetrance of the 845A homozygous genotype is low with respect to hepatocellular cancer in this population.
doi_str_mv 10.1016/S0140-6736(05)63143-1
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identifier ISSN: 0140-6736
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source Business Source Ultimate; ScienceDirect Freedom Collection
subjects Biological and medical sciences
Cancer
Carcinoma, Hepatocellular - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Genes
Genotype
Hemochromatosis - genetics
Hemochromatosis Protein
Histocompatibility Antigens Class I - genetics
HLA Antigens - genetics
Humans
Liver
Liver Neoplasms - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Membrane Proteins
Mutation
Tumors
title Haemochromatosis gene mutation in hepatocellular cancer
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