Clostridium septicum infection in children with cyclic neutropenia

Atraumatic Clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate. Although in adults it has been reported to occur mainly in patients with gastrointestinal malignancy, pediatric cases were always associated with neutropenia. About 70% of the cas...

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Bibliographic Details
Published in:The Journal of pediatrics 1997-08, Vol.131 (2), p.317-319
Main Authors: Bar-Joseph, Gad, Halberthal, Michael, Sweed, Yekiel, Bialik, Viktor, Shoshani, Oren, Etzioni, Amos
Format: Article
Language:English
Subjects:
Abdominal Muscles - microbiology
Adolescent
Adult
Biological and medical sciences
Cause of Death
Child
Chronic Disease
Clostridium - classification
Clostridium Infections - complications
Clostridium Infections - drug therapy
Clostridium Infections - surgery
Gas Gangrene - microbiology
Granulocyte Colony-Stimulating Factor - therapeutic use
Hematologic and hematopoietic diseases
Humans
Intestinal Perforation - microbiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Neutropenia - complications
Opportunistic Infections - complications
Periodicity
Shock, Septic - microbiology
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Summary:Atraumatic Clostridium septicum infection is rare in infancy and childhood and is associated with a high mortality rate. Although in adults it has been reported to occur mainly in patients with gastrointestinal malignancy, pediatric cases were always associated with neutropenia. About 70% of the cases were described in children with neutropenia caused by chemotherapy and 30% were found in children with cyclic neutropenia. No case was described in children with other forms of congenital severe neutropenia. We describe three children with cyclic neutropenia and severe Clostridium septicum infection, discuss the various possibilities of causation, and the need for prompt and aggressive treatment of this serious condition. (J Pediatr 1997;131: 317-9)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(97)70175-6