A shift in encephalitogenic T cell cytokine pattern is associated with suppression of EAE by intravenous immunoglobulins (IVIg)

Pooled human polyspecific IgG preparations for intravenous use (IVIg) have been used in a number of antibody mediated autoimmune diseases and recently in some T cell mediated disorders including multiple sclerosis, birdshot retinopathy and rheumatoid arthritis. Furthermore, IVIg has been proven bene...

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Bibliographic Details
Published in:Multiple sclerosis 1997-04, Vol.3 (2), p.153-156
Main Authors: Pashov, Anastas, Bellon, Blanche, Kaveri, Srini V, Kazatchkine, Michel D
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Cytokines - biosynthesis
DNA Primers
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - therapy
Female
Humans
Immunoglobulins, Intravenous - therapeutic use
Lymph Nodes - immunology
Lymphocyte Activation
Polymerase Chain Reaction
Rats
Rats, Inbred Lew
RNA, Messenger - biosynthesis
T-Lymphocyte Subsets - immunology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Transcription, Genetic
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Summary:Pooled human polyspecific IgG preparations for intravenous use (IVIg) have been used in a number of antibody mediated autoimmune diseases and recently in some T cell mediated disorders including multiple sclerosis, birdshot retinopathy and rheumatoid arthritis. Furthermore, IVIg has been proven beneficial in the corresponding animal models, i.e. experimental autoimmune encephalomyelitis (EAE), experimental autoimmune uveoretinitis and adjuvant arthritis respectively. The exact mechanisms for IVIg adion in T cell mediated disorders are still poorly understood. There is evidence that IVIg treatment in vitro and in vivo decreases or changes the kinetics of the secretion by normal PBMC of a number of cytokines and anti-proliferative effect of IVIg on T cells in vitro and in vivo has also been reported. It remains unclear though to what extent the IVIg effects in T cell mediated autoimmunity are related only to non-specifc T cell suppression and whether it also reshapes the autoimmune T cell cytokine profile. In this study we demonstrate that IVIg protects against EAE and that this beneficial effed is associated with a decreased proli feration of T cells specific for the immunizing antigen. Moreover, we show that these antigen-specific cells produce low amount of Th /-type cytokines and transfer an attenuated EAE
ISSN:1352-4585
1477-0970
DOI:10.1177/135245859700300218