Childhood moyamoya disease : hemodynamic MRI

Childhood moyamoya disease is a rare progressive cerebrovascular disease. To evaluate cerebral hemodynamics using dynamic Gd-DTPA-enhanced imaging in children with moyamoya disease. Eight children (2-11 years of age) with the clinical and angiographic findings typical of moyamoya disease, before and...

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Bibliographic Details
Published in:Pediatric radiology 1997-09, Vol.27 (9), p.727-735
Main Authors: ARIA TZIKA, A, ROBERTSON, R. L, BARNES, P. D, VAJAPEYAM, S, BURROWS, P. E, TREVES, S. T, SCOTT, R. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - diagnostic imaging
Cerebrovascular Circulation
Child
Child, Preschool
Contrast Media
Female
Gadolinium DTPA
Hemodynamics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Angiography
Magnetic Resonance Imaging - methods
Male
Medical sciences
Moyamoya Disease - diagnostic imaging
Moyamoya Disease - physiopathology
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Tomography, Emission-Computed, Single-Photon
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Summary:Childhood moyamoya disease is a rare progressive cerebrovascular disease. To evaluate cerebral hemodynamics using dynamic Gd-DTPA-enhanced imaging in children with moyamoya disease. Eight children (2-11 years of age) with the clinical and angiographic findings typical of moyamoya disease, before and/or after surgical intervention (pial synangiosis), underwent conventional MR imaging (MRI) and hemodynamic MR imaging (HMRI). HMRI used a spoiled gradient-echo with low flip angle (10 deg) and long TE (TR/TE = 24/15 ms) to minimize T 1 effects and emphasize T 2* weighting. Raw and calculated hemodynamic images were reviewed. Three-dimensional time-of-flight MR angiography (MRA) and perfusion brain single photon emission computed tomography (SPECT) were also performed. Abnormal hemodynamic maps resulting from vascular stenosis or occlusion and basal collaterals were observed in six patient studies. HMRI depicted perfusion dynamics of affected cerebrovascular territories, detected cortical perfusion deficits, and complemented conventional MRI and MRA. HMRI findings were consistent with those of catheter angiography and perfusion SPECT. Our preliminary experience suggests that HMRI may be of value in the preoperative and postoperative evaluation of surgical interventions in moyamoya disease.
ISSN:0301-0449
1432-1998
DOI:10.1007/s002470050212