Lupus-like anticoagulants and lower extremity arterial occlusive disease

Lupus-like anticoagulants (LLA), lupus anticoagulant and/or anticardiolipin antibody, are increasingly recognized in association with venous and arterial thrombotic events. We recently reviewed our experience with patients undergoing revascularization for lower-limb ischemia who were found to have L...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1989-11, Vol.80 (5 Pt 2), p.III54-III58
Main Authors: Eldrup-Jorgensen, J, Brace, L, Flanigan, D P, Schwarcz, T H, Fritsma, G, Meyer, J P, Schuler, J J
Format: Article
Language:English
Subjects:
Adult
Arterial Occlusive Diseases - blood
Autoantibodies - analysis
Blood Coagulation Factors - analysis
Blood Coagulation Factors - immunology
Cardiolipins - immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Leg - blood supply
Lupus Coagulation Inhibitor
Male
Middle Aged
Retrospective Studies
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Summary:Lupus-like anticoagulants (LLA), lupus anticoagulant and/or anticardiolipin antibody, are increasingly recognized in association with venous and arterial thrombotic events. We recently reviewed our experience with patients undergoing revascularization for lower-limb ischemia who were found to have LLA. Nine patients had LLA based on a prolongation of the partial thromboplastin time or by anticardiolipin assay by an enzyme-linked immunosorbent assay system. The ages of the patients ranged from 23 to 57 years. There were seven (78%) men, six (67%) blacks, two (22%) diabetic patients, and three (33%) hypertensive patients. One patient had systemic lupus erythematosus. All patients except one were cigarette smokers. Four patients had concurrent regulatory protein abnormalities: three protein C deficiencies, one protein S deficiency, and one plasminogen deficiency. The nine patients had 10 lower-extremity arterial reconstructions with two postoperative failures within 30 days. Patients were anticoagulated with heparin or aspirin after all but one operation. Patients at risk were identified on the basis of age (less than 51 years), unexplained early graft thrombosis, or history of venous or arterial thrombotic events. This group of patients is believed to be at risk for early postoperative thrombosis. Postoperative anticoagulation after revascularization for patients with LLA may be beneficial.
ISSN:0009-7322