Ras effectors and their role in mitogenesis and oncogenesis

Ras proteins are membrane-bound GTP-binding proteins that play a critical role in the control of cell growth. Through a large number of genetic and biochemical studies it is becoming increasingly evident that the biological activity of Ras proteins is mediated by multiple signaling pathways. This re...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 1997-08, Vol.75 (8), p.587-593
Main Authors: JONESON, T, BAR-SAGI, D
Format: Article
Language:English
Subjects:
Actins
Biological and medical sciences
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Cytoskeleton - physiology
Fundamental and applied biological sciences. Psychology
Genes, Tumor Suppressor
GTP Phosphohydrolases
GTP-Binding Proteins
GTPase-Activating Proteins
MAP Kinase Kinase 1
Mitogen-Activated Protein Kinase Kinases
Mitogens - physiology
Molecular and cellular biology
Oncogenes - physiology
Phosphatidylinositol 3-Kinases
Protein-Serine-Threonine Kinases
Protein-Tyrosine Kinases
Proteins
Proto-Oncogene Proteins c-raf
rap GTP-Binding Proteins
ras GTPase-Activating Proteins
ras Proteins - genetics
ras Proteins - physiology
Signal Transduction - physiology
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Summary:Ras proteins are membrane-bound GTP-binding proteins that play a critical role in the control of cell growth. Through a large number of genetic and biochemical studies it is becoming increasingly evident that the biological activity of Ras proteins is mediated by multiple signaling pathways. This review provides an account of the target proteins that interact with Ras and the functional consequences of these interactions. The relative contribution of the different Ras effector pathways to the mitogenic and oncogenic effects of Ras are discussed.
ISSN:0946-2716
1432-1440
DOI:10.1007/s001090050143