Presence of paf-acether in human thymus

Paf-acether (paf) is a phospholipid mediator of inflammation endowed with major immunoregulatory properties. The present study demonstrates that human thymus contains large amounts of paf, as well as paf precursors. In addition, isolated thymic cells produced paf under ionophore stimulation. Paf fro...

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Bibliographic Details
Published in:FEBS letters 1989-10, Vol.257 (1), p.49-51
Main Authors: Salem, Patrick, Denizot, Yves, Pitton, Christina, Dulioust, Anne, Bossant, Marie-Jeanne, Benveniste, Jacques, Thomas, Yolene
Format: Article
Language:English
Subjects:
Animals
Aspirin - pharmacology
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - physiology
Child, Preschool
Chromatography, Gas
Chromatography, High Pressure Liquid
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Inflammation
Molecular and cellular biology
Platelet Activating Factor - analysis
Platelet Activating Factor - isolation & purification
Platelet Activating Factor - pharmacology
Rabbits
Thymus Gland - analysis
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Summary:Paf-acether (paf) is a phospholipid mediator of inflammation endowed with major immunoregulatory properties. The present study demonstrates that human thymus contains large amounts of paf, as well as paf precursors. In addition, isolated thymic cells produced paf under ionophore stimulation. Paf from thymus exhibited the same biological and physicochemical properties as synthetic paf. The purity and molecular structure of paf from thymus were further characterized by reverse-phase HPLC and gas chromatography with electron-capture detection. These findings may have important implications since thymus microenvironment is essential in the proper development of bone marrow progenitors committed to the T cell lineage into thymocytes capable of emigrating to the periphery as functional T lymphocytes. Platelet-activating factor-acether; Thymus
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)81783-1