Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 1997-08, Vol.131 (2), p.167-172
Main Authors: Heldwein, Kurt A, Duncan, Janet E, Stenzel, Peter, Rittenberg, Marvin B, Stenzel-Poore, Mary P
Format: Article
Language:English
Subjects:
Animals
Corticotropin-releasing hormone
Endotoxin
Escherichia coli
Female
Gene Expression Regulation
Heart
Lipopolysaccharides - pharmacology
Mice
Mice, Inbred C57BL
Muscle, Skeletal - metabolism
Myocardium - metabolism
Receptor
Receptors, Corticotropin-Releasing Hormone - genetics
Regulation
RNA, Messenger - metabolism
Skeletal muscle
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Summary:We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.
ISSN:0303-7207
1872-8057
DOI:10.1016/S0303-7207(97)00103-2