Caloric restriction enhances evoked DA overflow in striatum and nucleus accumbens of aged Fischer 344 rats

Previous studies have shown deficits in DA neuronal systems in senescence. Other studies indicate that prolonged dietary restriction can attenuate many of the detrimental effects of age. We have shown previously using in vivo electrochemistry that K+-evoked striatal DA overflow decreases as a functi...

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Bibliographic Details
Published in:Brain research 1997-07, Vol.763 (2), p.276-280
Main Authors: Diao, Li Hong, Bickford, Paula C, Stevens, James O, Cline, Elizabeth J, Gerhardt, Greg A
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Caloric restriction
Corpus Striatum - chemistry
Corpus Striatum - metabolism
DA overflow
Data Interpretation, Statistical
Diet
Dopamine - metabolism
Electrochemistry, in vivo
Electrophysiology
Energy Intake - physiology
Female
Mesolimbic
Mesostriatal
Neurons - chemistry
Neurons - drug effects
Nucleus Accumbens - chemistry
Nucleus Accumbens - metabolism
Potassium - pharmacology
Potassium Channels - physiology
Rats
Rats, Inbred F344
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Summary:Previous studies have shown deficits in DA neuronal systems in senescence. Other studies indicate that prolonged dietary restriction can attenuate many of the detrimental effects of age. We have shown previously using in vivo electrochemistry that K+-evoked striatal DA overflow decreases as a function of age. This was a regional effect that appeared to be due to functional changes in DA neurons, rather than a decrease in the storage and synthesis of DA. In the present studies, we used in vivo electrochemistry to investigate the effects of caloric restriction on age related decreases in K+-evoked DA overflow along a dorsal to ventral axis in the striatum of aged female Fischer 344 rats. Aged (26–28-month-old) diet restricted animals (DRF) showed evoked DA overflow that was significantly greater in amplitude and duration compared to aged (26–28-month-old) ad lib fed animals (ALF). These results provide additional evidence that decreased DA neuronal function resulting from age is improved by caloric restriction.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00494-0