Pyrrolizidine Alkaloids from Heliotropium rotundifolium

Heliotropium rotundifolium was shown to contain, in addition to the previously isolated europine [1], three other alkaloids: heliotrine [2], lasiocarpine [3], and a new alkaloid identified as 5'-acetyleuropine [4]. The alkaloids were isolated by dccc and the structures established by spectrosco...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1989-07, Vol.52 (4), p.726-731
Main Authors: Asibal, Clarita F, Gelbaum, Leslie T, Zalkow, Leon H
Format: Article
Language:English
Subjects:
ALCALOIDE
ALCALOIDES
ALKALOIDS
Biological and medical sciences
Chemical Phenomena
Chemistry
ESPECTROSCOPIA RMN
Gas Chromatography-Mass Spectrometry
General pharmacology
HELIOTROPIUM
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
NMR SPECTROSCOPY
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - analysis
Pyrrolizidine Alkaloids - isolation & purification
Pyrrolizidine Alkaloids - pharmacology
SPECTROSCOPIE RMN
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Summary:Heliotropium rotundifolium was shown to contain, in addition to the previously isolated europine [1], three other alkaloids: heliotrine [2], lasiocarpine [3], and a new alkaloid identified as 5'-acetyleuropine [4]. The alkaloids were isolated by dccc and the structures established by spectroscopic means (1H and 1H- 13CHETCOR nmr and ms), physical properties (melting points and/or optical rotations), comparison with authentic samples, or by semi-synthesis.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50064a010