Enhanced Expression of Endothelial Oxidized Low-Density Lipoprotein Receptor (LOX-1) in Hypertensive Rats

Oxidized low-density lipoprotein (Ox-LDL) has been implicated in the attenuated endothelium-dependent vasodilatation in atherosclerotic arteries and, possibly, in hypertension. The aim of the present study was to investigate gene expression of recently-identified endothelial Ox-LDL receptor (LOX-1)...

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Published in:Biochemical and biophysical research communications 1997-08, Vol.237 (3), p.496-498
Main Authors: Nagase, Miki, Hirose, Shigehisa, Sawamura, Tatsuya, Masaki, Tomoh, Fujita, Toshiro
Format: Article
Language:English
Subjects:
Animals
Aorta
Blood Pressure
DNA Primers
Endothelium, Vascular - metabolism
Hypertension - genetics
Hypertension - physiopathology
Male
Organ Specificity
Polymerase Chain Reaction
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
Receptors, LDL - biosynthesis
Receptors, Oxidized LDL
RNA, Messenger - biosynthesis
Scavenger Receptors, Class E
Sodium, Dietary
Species Specificity
Transcription, Genetic
Veins
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Summary:Oxidized low-density lipoprotein (Ox-LDL) has been implicated in the attenuated endothelium-dependent vasodilatation in atherosclerotic arteries and, possibly, in hypertension. The aim of the present study was to investigate gene expression of recently-identified endothelial Ox-LDL receptor (LOX-1) in hypertensive state. SHR-SP, WKY, Dahl salt-sensitive (DS) and salt-resistant rats (DR) were fed salt-loaded or control diet. RNA was extracted from the aorta and vein. LOX-1 expression was examined by Northern blotting. LOX-1 mRNA was low in the aorta and vein of WKY, whereas it was markedly upregulated in those of SHR-SP. LOX-1 expression was low in the aorta of DR on both diets and of DS on a control diet, whereas it was elevated in that of salt-loaded DS. These results indicated that LOX-1 expression in the aorta and vein was upregulated in hypertensive rats, which may be involved in the impaired endothelium-dependent vasodilatation in these rats.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1997.7176