Evidence for the involvement of endogenous aspartate in the mediation of carotid chemoreceptor reflexes in the rostral ventrolateral medulla of the rat

2-Amino-5-phosphonovalerate (AP5; 153 pmol) injected into the rostral ventrolateral medulla (RVLM) inhibited pressor responses induced by carotid chemoreceptor stimulation. AP5 also inhibited pressor responses to aspartate (0.75 nmol) but not to glutamate (0.53 nmol) similarly injected. High K+ (50...

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Bibliographic Details
Published in:Neuroscience letters 1997-08, Vol.232 (2), p.103-106
Main Authors: Kubo, Takao, Asari, Tetsuya, Amano, Motoaki, Hagiwara, Yukihiko, Fukumori, Ryuji
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
Animals
Aspartate
Aspartic Acid - metabolism
Aspartic Acid - pharmacology
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Blood vessels and receptors
Carotid body
Carotid Body - drug effects
Carotid Body - physiology
Chemoreceptor
Chemoreceptor Cells - physiology
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Glutamate
Glutamic Acid - metabolism
Glutamic Acid - pharmacology
Male
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Microinjections
Phenylephrine - pharmacology
Potassium - pharmacology
Rats
Rats, Wistar
Reflex
Release of aspartate
Rostral ventrolateral medulla
Stereotaxic Techniques
Vertebrates: cardiovascular system
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Summary:2-Amino-5-phosphonovalerate (AP5; 153 pmol) injected into the rostral ventrolateral medulla (RVLM) inhibited pressor responses induced by carotid chemoreceptor stimulation. AP5 also inhibited pressor responses to aspartate (0.75 nmol) but not to glutamate (0.53 nmol) similarly injected. High K+ (50 mM) released endogenous aspartate and glutamate in a Ca2+-dependent manner from the RVLM. Chemoreceptor stimulation caused a release of aspartate but not of glutamate in the RVLM, and sinus nerve denervation abolished the release of aspartate. Increases in blood pressure induced by intravenous phenylephrine did not release aspartate. These results support the hypothesis that endogenous aspartate in the rat RVLM is involved in the mediation of chemoreceptor reflexes.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(97)00584-3