Neonatal Antibody-Dependent Cellular Cytotoxic Antibody Levels Are Associated with the Clinical Presentation of Neonatal Herpes Simplex Virus Infection

The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal antiHSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 770/0 had localized and 23% had dissemina...

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Bibliographic Details
Published in:The Journal of infectious diseases 1989-11, Vol.160 (5), p.770-776
Main Authors: Kohl, Steve, West, M. Stewart, Prober, Charles G., Sullender, Wayne M., Loo, Lian S., Arvin, Ann M.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Viral - immunology
Antibody dependent cell cytotoxicity
Antibody-Dependent Cell Cytotoxicity - immunology
Biological and medical sciences
Encephalitis
Encephalitis - complications
Female
Herpes Simplex - immunology
Human viral diseases
Humans
Infant, Newborn - immunology
Infant, Newborn, Diseases - immunology
Infants
Infections
Infectious diseases
Major Articles
Medical sciences
Neonatal diseases
Neutralizing antibodies
Pregnancy
Pregnancy Complications, Infectious - immunology
Simplexvirus
Simplexvirus - immunology
Skin diseases
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viruses
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Summary:The role of antiviral antibodies in protection against neonatal herpes simplex virus (HSV) infection remains controversial. The relationship between neonatal and maternal antiHSV antibodies and disease presentation was analyzed in 47 babies. Of the neonates, 770/0 had localized and 23% had disseminated HSV infection. Antibody-dependent cellular cytotoxic (ADCC) antibodies were evaluated in comparison with HSV neutralizing antibodies. High maternal (>1:104) or neonatal (>1:103) anti-HSV ADCC antibody levels or high neonatal antiviral neutralizing levels (>1:20) were independently associated with an absence of disseminated HSV infection. Cochran-Mantel-Haenszel analysis demonstrated that ADCC levels were associated with disease status (P
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/160.5.770